DET LLC is developing nano-based delivery for prevention and treatment of infectious diseases such as Flu, HIV, Lyme diseases, Bacteria/fungal/virus infections, and Biologic Agents.

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Key Experiences:

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• Cheng, X. & Cao, F. Liposomal Troponoid Compound Formulation, U.S. Provisional Patent Application No. 62/894,187, Filed on 08/30/2019.

• Cheng X, Carson K, Mcdonough J, Gourapura RG, Lee CW, Dhakal S, inventors; A liposomal subunit flu vaccine formulation, Nov 19, 2019. U.S. Patent Award No. 10,478,488.

• Dhakal, S., Cheng, X., Salcido, J., Renu, S., Bondra, K., Lakshmanappa, Y. S., . . . Renukaradhya, G. J. (2018). Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs. Int J Nanomedicine, 13, 6699-6715. doi:10.2147/ijn.s178809

• XG Cheng, Nitin N, Wellinghoff ST, Rossini G, ‘Coating for medical implants’, US Patent award number, 8,652,505. Award date: 02/18/2014

• TE Swanson, XG Cheng, C Friedrich, The Development of Chitosan-vancomycin Antimicrobial Coatings on Titanium Implants, Journal of Biomedical Materials Research Part A, 97A/2 (2011), 167-176.

• XG Cheng, Synthesis of Novel Particulate Adjuvants for Vaccine and Preliminary Evaluation, Invited talk at the 2013 San Antonio Vaccine Development Symposia, San Antonio, TX

• XG Cheng; Santosh Dhakal; John Salcido; Kenneth Carson; Chang Won Lee; Renukaradhya J. Gourapura “Preparation and Preliminary Evaluation of a Liposomal Formulation of Swine Flu Subunit Vaccine”, Vaccine Development Center of San Antonio, 11/10/2016

• XG Cheng; John Salcido; Jonathan Keck; Rishein Gupta; Neal Guentzel Formulation of Subunit Peptide Chlamydia Vaccines Using Custom-Made Liposomes, Vaccine Development Center of San Antonio Meeting, 11/10/2016

• XG Cheng, Dhakal S, Gourapura RJ, Keck J, Gupta R, Gentzel N, editors. Liposome-based Nano Vaccine Development. Vaccine development center of San Antonio Research Conference; 11/16/2017-11/17/2017; San Antonio, TX.